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The higher RMSD, RMSF, RoG and less hydrogen bonding between proposed mutants G75C (rs763687242), F167S (rs2107818892), and L168Q (rs373838463) as compared to the wild-type, demonstrated the disruption in GPx1 structure due to mutations
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10.1016/j.bcp.2005.10.005 Biochem
Science 282 , 22582261 (1998)
CagriSema appears closest to a possible approval given its reported regulatory submission, while retatrutide leads on reported efficacy
