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P ryor and Porter postulated several alternative mechanisms (2) that were inspired by the observation that the formation of HNE can be catalyzed by iron which "suggests the intermediacy of a hydroperoxide which is reduced to form an alkoxyl radical." An unlikely possibility involves the generation of a hydroperoxy dihydropyran intermediate

6, revealed a decrease in the area per lipid and a slight increase in membrane width, while curvature decreased and lipid diffusion remained constant
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