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KawasoeSMaruguchiYKajiyaSUenomachiHMiyataMKawasoeMet alMechanism of the blood pressure-lowering effect of sodium-glucose cotransporter 2 inhibitors in obese patients with type 2 diabetes

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Feedback-regulated enzyme activitydegradative enzyme activity increases with mucus layer thickness, whereas metabolic feedback inhibition suppresses enzyme gene expression when mucin availability is low, preventing excessive depletion [49, 50]

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A recent study has demonstrated that an acute increase in the intracellular concentration of ROS inhibits the glycolytic enzyme pyruvate kinase M2 (PKM2) through the oxidation of Cys358 ( NRF2 INHIBITORS FOR ANTICANCER THERAPY Due to the multifaceted roles of Nrf2 in cancers, Nrf2 inhibitors could be effective for anticancer therapy