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NAD+ is an essential **bioactive** coenzyme that declines with age, and supplementation can help maintain metabolic efficiency during caloric restriction

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While the implications for SARM1 in regulating axonal fate are well-established, the sensing mechanisms of this protein complex toward NAD + , NMN, or even possibly toward other NAD + metabolites are not fully understood, and may suggest that also the other NAD + metabolites could regulate more biological processes than initially thought 54

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References: Office of Dietary Supplements, NIH