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Study 1: Knee pain (2021)
Common symptoms among adolescent patients include irregular menstruation, oligomenorrhea, and amenorrhea, with the latter being the most frequently observed symptom, followed by oligomenorrhea and abnormal uterine bleeding (AUB) (Meczekalski et al., 2023

Although the current therapeutic practices have significant variability in routes and dosage regimens, we concluded that management of IGS predominantly centers on lifelong Vitamin B12 supplementation, which is sufficient for preventing hematological and neurological abnormalities associated with this disorder

In adolescent patients with PCOS, these side effects may have a noteworthy impact on efficacy

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Miller GE, Chen E

We hypothesized that this was because of tesofensines ability to modulate neuronal activity in the LH
