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doi: 10.1074/jbc.272.46.28875 42 CostelloLCLiuYZouJFranklinRB

The activation of these transcription factors has been correlated with increased mitochondrial biogenesis, significantly improving muscle endurance capacity and attenuating insulin resistance in obesity and type 2 diabetes [38]

Tetsuro Suzuki, Hamamatsu University School of Medicine, Japan Copyright 2012 Moriishi and Matsuura

Advantages : vascular action, peripheral circulation support, sometimes prescribed in cases of lower limb arteritis or angina pectoris

MC1R-driven cAMP elevation simultaneously activates MITF for melanogenesis and suppresses NF-B for anti-inflammatory effects