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[Google Scholar] 382.Choi S, Delaney S, Orbai L, Padgett EJ, Hakemian AS

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Inhibition of IGF-1R with figitumumab (anti-IGF-IR antibody) leads to downregulated receptor expression, inhibition of tumor growth [113], and radiosensitization of cancer cells [114]

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Its mechanism involves binding to and stabilizing the mRNA transcript of ferroptosis suppressor protein 1 (FSP1), a key component of a parallel antioxidant system that utilizes ubiquinone (CoQ10) to neutralize lipid peroxides, thereby establishing a crucial post-transcriptional regulatory checkpoint (151)