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Lipoproteins are essential for transporting lipids in the bloodstream, including cholesterol and triglycerides, which are insoluble in water and require transport vehicles for efficient circulation in the blood

Decreased cholesterol levels mean that hepatic FXR is inhibited, at which point CYP7A1 expression is elevated and cholesterol is converted to more bile acids to be stored in the gallbladder, which may lead to impaired hepatic function or cholestasis when the liver synthesizes too much bile acids 10

J Peripher Nerv Syst 12(3):210215 Cavaletti G, Frigeni B, Lanzani F, Mattavelli L, Susani E, Alberti P, Cortinovis D, Bidoli P (2010) Chemotherapy-induced peripheral neurotoxicity assessment: a critical revision of the currently available tools