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Dysfunctions in neurotransmitter signaling, affecting cholinergic and dopaminergic pathways in particular, have been involved in the occurrence of cognitive impairments

The binding of CD40 on OFs and CD40L (CD154) on T cells in TED patients leads to OFs proliferation, and blocking CD40 or CD40L significantly reduces OFs proliferation

PMID 27549768

** This product has been developed and manufactured in accordance with the requirements of EN 17444 as of the production date of the batch

These can include rapid heartbeat, chest pain, confusion, muscle cramps and weakness, hives, skin rashes, and difficulty breathing or swallowing [1]

10.1177/0891988712436688 62 FouadA