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Mal de Dbarquement Syndrome (MdDS) Mechanism : After prolonged passive motion (boat, plane), central adaptation fails to readjust to stable ground, producing persistent rocking

However, anecdotal reports from online forums cited in a 2025 systematic review included anxiety and panic attacks, depression and anhedonia, insomnia, heart palpitations, fatigue and weakness, and loss of appetite

This mechanism underpins its fibroblast migration-promoting effects and helps explain its capacity to accelerate tissue repair at a cellular motility level independent of proliferation

Cell Microbiol (2012) 14:4606

[1] Causes of generalised hyperpigmentation include excessive sun exposure, drugs, Addisons disease and nutritional disorder such as Vitamin B12 deficiency