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Understanding that high B12 serves primarily as a biochemical marker prompting further investigation is essential for appropriate clinical management and identifying potentially significant underlying pathology

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Science of the Total Environment, 801: 149709 Mandal A, Sinha C, Jena A K, Ghosh S, Samanta A (2010)

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Rather than measuring B12 directly, the MR used 8 genetic variants (SNPs) known to raise B12 levels as a proxy for lifelong B12 levels