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doi: 10.2174/1874609811205030010

Karp et al., 2000

Although this review has emphasized the promising potential of natural compounds, it is important to recognize that inconclusive or unfavorable dataparticularly from preclinical studies involving transgenic mouse and zebrafish modelsalso exist

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It Concentrates Where You Need It Most Once absorbed, ergothioneine is transported via OCTN1 and concentrates in tissues most vulnerable to oxidative stress: Erythrocytes (red blood cells) Eye lens Liver and kidney Brain (particularly mitochondria and nucleus) Skin Bone marrow and semen This preferential accumulation in stress-vulnerable tissues strongly supports its protective role

Pathogen-sensing and regulatory T cells: integrated regulators of immune responses