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The goal of titration is finding your minimum effective dose, not reaching the maximum

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Comparison of different measurements of intestinal permeability in inflammatory bowel disease

doi: 10.1289/ehp.6704 121 BhuiyanMARWangLShaidAShanksRADingJ

Using sterile water instead of bacteriostatic shortens usable lifespan to 72 hours and increases contamination risk in multi-dose vials

Patients with pernicious anaemia, malabsorption disorders (such as Crohn's disease or coeliac disease), or following gastric surgery require regular B12 supplementation to prevent serious complications including megaloblastic anaemia and neurological damage