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Cobalamin separates from the protein during digestion, and a substance called intrinsic factor binds to cobalamin for the body to absorb it into the blood

This leads to damage to tissue cells, including vascular ECs ( Elevated Hcy levels have been implicated in perturbing fat metabolism, presenting a potential link between Hcy and adipose tissue dysfunction, which further contributes to cardiovascular disease risk

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NNMT is highly expressed in the white adipose tissue of individuals with obesity and diabetes, where it acts as a "metabolic brake," slowing down the rate at which cells burn energy