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[DOI] [PMC free article] [PubMed] [Google Scholar] Tinari S

Central to this concept linking neural and systemic functions is the concept of allostasis (adaptation) and allostatic load/overload (pathophysiology) [6] that emphasizes the role of endogenous mediators for adaptation in contributing to pathologies, including MDD, when activated persistently or dysregulated under circumstances of toxic stress and health-damaging behaviors (poor diet, excessive alcohol consumption, sleep deprivation and circadian disruption)

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miR-135b-3p promotes cardiomyocyte ferroptosis by targeting GPX4 and aggravates myocardial ischemia/reperfusion injury

Consequently, it is possible that the supplemented ingredient operates through improving antioxidant status and anti-inflammatory parameters, hence decreasing muscle damage and fatigue
