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3.5 Multi-omics integration and interaction Omics integration is not merely the aggregation of layered datasets, but rather aims to identify cascade pathways and construct coordinated networks across biological levels

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It is presumed that EGCG activates the 67LR receptor, leading to subsequent activation of the apoptotic signaling Akt/eNOS/NO/cGMP/PKC pathway, whereas the upregulation of cyclic guanosine monophosphate (cGMP) (e.g., by phosphodiesterase-5 inhibitor vardenafil) acts as a rate-determining process of 67LR-dependent apoptosis [70,71,72]

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