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5-aza-2-deoxy-cytidine (decitabine) and 5-azacytidine were first successfully studied in hematological malignancies and myelodysplastic syndrome (MDS) and were approved by the FDA in 2006 for treating MDS, where they exhibit anti-tumor activity through the inhibition of DNA methylation (182)

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Finally, SLC30A10 mediates the efflux of excess Mn from neurons, and Mn that is not utilized by the liver is excreted from hepatocytes into the bile via SLC30A10 located at the apical canalicular membrane