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The development of RNAi drugs and small molecule inhibitors targeting NNMT is facing several challenges

Propionylcarnitine (C3) and its ratios with acetylcarnitine (C3/C2) and palmitoylcarnitine (C3/C16) In addition to the four canonical markers discussed above, vitamin B 12 deficiency leads to accumulation of propionylcarnitine (C3) (Sarafoglou et al., 2011), which is a marker of methylmalonic aciduria and propionic acidemia

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5-Amino-1MQ doesn't act on appetite, it works by inhibiting NNMT, which shifts cell metabolism toward fat oxidation and muscle preservation