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doi: 10.3389/fcell.2025.1671152 Received 22 July 2025 Revised 08 October 2025 Accepted 20 October 2025 Published 01 December 2025 Volume 13 - 2025 Edited by Nimanthi Jayathilaka, University of Kelaniya, Sri Lanka Reviewed by Theodoros Androutsakos, National and Kapodistrian University of Athens, Greece Arturo Raya-Sandino, University of Michigan, United States Updates Copyright 2025 Ferris, Subitoni Antonio and Al-Sadi

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however, its abilities to improve tpe 1 collagen and increase blood flow via angiogenesis means it is a powerful peptide for wound healing and overall regeneration following damage

10.1038/srep00955 39 RichardsT

For the H 2 group, after silica modeling, mice were given the same vehicle (1% CMC-Na) through gavage and made to inhale hydrogen/oxygen mixture for 2 h per day for 6 days a week

Our results are also consistent with publications showing that CAV-1 reduction upregulates angiogenesis-related factors as evidenced by an inverse correlation between CAV-1 and VEGF in osteosarcoma 28 , increased CXCR12 expression in CAV-1 silenced fibroblast 29 , and a significant negative correlation between osteopontin and caveolin-1 levels in human osteoarthritic cartilage 30