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That is, PER:CRY and CRY:CRY repress the CLOCK:BMAL1-driven transcription of Pers and Crys
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Taken together, these results suggest that Spint1a-deficient keratinocytes accumulate DNA breaks and have increased susceptibility to DNA stressors

Mihanfar, A

[PMC free article] [PubMed] [Google Scholar] 19.Portincasa P, Di Ciaula A, de Bari O, Garruti G, Palmieri VO, Wang DQ
