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In the TMLHE gene knockout mouse model, the carnitine biosynthetic pathway is inhibited due to the loss of TMLD activity in the liver, affecting the availability of carnitine in the heart, significantly reducing the rate of synthesis of LCACs, and contributing to the protection of mitochondrial function after myocardial IRI [215]

Ann Neurol 1994;36:680-1

[DOI] [PubMed] [Google Scholar] Tauqir S., Israr M., Rauf B., Malik M.O., Habib S.H., Shah F.A., Usman M., Raza M.A., Shah I., Badshah H., Ehtesham E., Shah M

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On the other hand, hyperhomocysteinemia, one of the risk factors of migraine attacks, could be regulated by methyl donors including B6, B9, and B12 (58)

Proper screening and medical supervision reduce health risks significantly