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This distinct form of cell death, characterized by iron-dependent phospholipid peroxidation, is influenced by various cellular metabolic processes, including redox balance, iron metabolism, mitochondrial function, and the metabolism of amino acids, lipids, and carbohydrates, alongside numerous signaling pathways pertinent to various diseases (Jiang et al., 2021)

In AD hippocampus, GST and MRP-1 are covalently bound by the lipid peroxidation product HNE, rendering them inactive [13

[DOI] [Google Scholar] 114.Jangra M., Devi S., Satpal, Kumar N., Goyal V., Mehrotra S

Friedenreich CM, Cook LS, Wang Q, Kokts-Porietis RL, McNeil J, Ryder-Burbidge C, et al

Here is a graphical representation of what is going on in a mitochondrion in depression

Thorax 67 , 309314 (2012)