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This approach has merit but still works indirectly and much more slowly than IV therapy

In addition, we may need to compare the potential differences between data from different tissues (for example, plasma and CSF)

There are several mechanisms which may underlie the association between type II diabetes and dementia, including neurotoxicity resulting from hyperglycemia, alterations in amyloid metabolism, increased risk of cerebrovascular disease, and a combination of these mechanisms (6)

The choice of localized microinjection was based on its ability to deliver a continuous and controlled release of the agents directly into the basement membrane, the site where melanocytes reside

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