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They can be found in vertebrate and invertebrate animals, plants and fungi

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The major bioactive constituent of licorice is glycyrrhizin (also called glycyrrhizic acid) which consists of two molecules of glucuronic acid (a type of sugar) and one molecule of glycyrrhetic acid

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4.2.4 Stimuli-responsive nanoparticles Factors influencing drug release are incorporated into the nanoparticle, enabling distinct controlled-release mechanisms and paving the way for various optimization and design strategies

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One study of drug release of papaverine HCl in a gel vehicle found an alcohol-containing penetration enhancer resulted in drug penetration both in vitro and in vivo in rabbits

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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Hu Q, Zhang Y, Lou H, Ou Z, Liu J, Duan W, et al

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