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Focusing on neurological and cardiovascular disorders that require precision, targeted strategies can bypass the BBB to concentrate drugs at lesions, enhancing efficacy while reducing toxicitycrucial for slowing neurological diseases with fewer side effects

Sci Pharm 85(1):4 [DOI] [PMC free article] [PubMed] [Google Scholar] Kandemir MF, Kkler S, alayan C, Gr C, Batl AA, Gulcin I (2017b) Therapeutic effects of silymarin and naringin on methotrexate-induced nephrotoxicity in rats: biochemical evaluation of anti-inflammatory, anti-apoptotic and anti-autophagic properties

This accumulation indicates a failure in autophagosome maturation and lysosomal fusion, subsequently hindering the clearance of toxic proteins such as A and tau [59,133]

Semaglutide should not be used for the treatment of type 1 diabetes mellitus

The delicate balance between ROS production and the ROS scavenging system is pivotal for maintaining normal physiological function

F., Heinecke, J