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21 Clinical Presentation Regardless of whether acetaminophen toxicity occurs because of a single overdose or after repeated supratherapeutic ingestion, the progression of acetaminophen poisoning can be described in four sequential phases: preclinical toxic effects (phase one), hepatic injury (phase two), hepatic failure (phase three), and recovery (phase four)

Nevertheless, key questions remain regarding the enzymatic control, cell-type specificity, and in vivo relevance of lactylation, warranting deeper mechanistic and translational investigation

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[DOI] [PubMed] [Google Scholar] 75.Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ

J Plant Physiol 174:515 Bhattachrjee S (2005) Reactive oxygen species and oxidative burst: roles in stress, senescence and signal transducation in plants

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