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Although GSH failed to restore 5-hydroxytryptamine (5-HT/serotonin) levels in embryos treated with 10 M CdCl2, the Cd-induced suppression of heart rate was reversed by the serotonergic (5-HTergic) modulators quipazine and fluoxetine, suggesting the involvement of the 5-HT system in Cd-induced cardiotoxicity

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The and classes of GSTs play a regulatory role in the mitogen-activated protein (MAP) kinase pathway that participates in cellular survival and death signals via protein:protein interactions with c-Jun N-terminal kinase 1 (JNK1) and ASK1 (apoptosis signal-regulating kinase)