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The detoxification reactions comprise the first four steps of mercapturic acid synthesis, [19] with the conjugation to GSH serving to make the substrates more soluble and allowing them to be removed from the cell by transporters such as multidrug resistance-associated protein 1 (MRP1)

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doi: 10.1056/nejm199908193410801 52 Morreale de EscobarGObregonMJEscobar del ReyF

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The key symptoms are 1) cough, 2) sputum volume and/or consistency, 3) sputum purulence, 4) breathlessness and/or exercise intolerance, 5) fatigue and/or malaise, and 6) haemoptysis [125]

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