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However, these changes do not translate to a significant displacement of the cytoplasmic region of TM5

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PMID: 19381278 Erickson JD, Varoqui H (2000): Molecular analysis of vesicular amine transporter function and targeting to secretory organelles

Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation

doi: 10.1093/bioinformatics/btm254