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They are formed in the body from normal metabolism (such as converting food to energy) but are increased by exposure to environmental toxins, such as cigarette smoke and air pollution

Oxidative stress is a complex biochemical process involving the interaction of multiple oxidative and antioxidant pathways

In AD models, decreased spine density (number of spines per unit length of dendrite) and altered spine size (spine head volume) manifested as varying changes in the types of spines have been widely reported (Calabrese et al., 2007