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Generally, PD shows major pathology through dopaminergic neuron degeneration in the substantia nigra, causing an approximately 80% decline of dopamine levels in the striatum ( Glutamate represents the dominant excitatory neurotransmitter across central nervous system pathways

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Clin Chem 65(9):11411152

J Endocrinol 200(2):207 Atia T et al (2022) Vitamin D supplementation could enhance the effectiveness of glibenclamide in treating diabetes and preventing diabetic nephropathy: a Biochemical, Histological and Immunohistochemical Study