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68 In many cases, a patient may not be able to tolerate one or more drugs

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By integrating the aforementioned strategies to construct a multi-level, high-precision experimental model system that closely approximates the pathological essence of human GA, we are able to not only enhance our comprehension of disease mechanisms, but also substantially expedite the preclinical advancement and translational headway of innovative therapeutic approaches

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Autophagy is involved in the metabolism coupling between TME and AML Recent studies have demonstrated that cancer cells can remodel the microenvironment into a self-reinforcing tumor microenvironment (TME) to support their survival and proliferation [127, 128]

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