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ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status

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The role of cell type and sensitivity in ferroptosis is intricate and tissue-specific

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PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells

Subsequently, Cys and Glu are conjugated by -glutamylcysteine synthetase (-GCS) to form -glutamylcysteine (-GC), which is finally combined with glycine by glutathione synthetase (GS) to produce GSH ( Accumulating evidence has uncovered two additional parallel pathways that act as critical regulators of ferroptosis