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FIGURE 8 The aforementioned abnormalities at the molecular level (downregulation of the Nrf2/HO-1 axis and GPX4) and subcellular structural level (neuronal somata and mitochondrial impairment) were consistent with the GSH metabolism perturbations identified by multi-omics analyses, collectively reflecting oxidative stress-associated damage in the hippocampus during SAE

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Advancements in organoid-based drug discovery: revolutionizing precision medicine and pharmacology

Ginzburg E, Lin A, Sigler M, Olsen D, Klimas N, Mintz A

Steroid hormones, in turn, are oxygenated forms of cholesterol, a characteristic they share with bile acids and oxysterols ( Any discussion of the steroidogenic mitochondria of the adrenal gland must revolve around the mitochondrial steroidogenic enzymes