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Although pharmacological stimulation of the hypothalamicpituitarygonadal axis using agents such as human chorionic gonadotropin and selective oestrogen-receptor modulators may promote recovery, these interventions require specialised medical supervision

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The study also excluded individuals with pes cavus (Lynch et al., 2023), which is one of the main musculoskeletal abnormalities associated with the disease (Milne et al., 2016), and it is unknown what improvements, if any, omaveloxolone would have on FRDA patients with pes cavus