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Therefore, the inability to maintain NRF2 protein expression is directly associated with poor prognosis in clinical patients diagnosed with lung cancer.16,19,20 The Cancer Genome Atlas (TCGA) data showed that approximately 30% of human lung cancers harbor mutations in KEAP1 or NFE2L2 genes that ultimately lead to NRF2 stabilization and upregulation of its downstream genes.21,22 NRF2 signaling pathway in oncogenesis Loss of KEAP1 function leads to defective activation of the NRF2 signaling pathway in NSCLC cells, resulting in resistance to chemotherapeutic agents.13 The inability of KEAP1 to bind NRF2 due to both mutations results in increased NRF2 accumulation and downstream gene transcription

These emerging therapeutic intervention strategies provide new strategies for regulating ROS levels and hold promise for playing important roles in the treatment of cancer and other diseases

781 Bioinformatics analysis showed that CHAC1 is a key gene in the process of ferroptosis in patients with ischemic stroke

The main physicochemical properties of L-theanine are shown in Table 1

Growing concerns about the environmental impact of agriculture are accelerating the shift from resource-intensive animal foods to high-protein plant-based foods (Bryant 2022

This idea was further supported when similar phenotypes were observed across ferroptosis-sensitive and ferroptosis-resistant cancer cell lines (Extended Data Fig