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Proc Natl Acad Sci U S A 106 (22): 9109-14

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Remarkably, Erastin highly increased OCR in LDHB KD (siLDHB + Erastin) but not in control A549 cells (siNT + Erastin) ( Figure 4d, Supplementary Figure 8c ), suggesting that cancer cells subjected to combined inhibition of LDHB and SLC7A11 undergo a high level of OXPHOS

This injury may represent an early event that initiates glomerulosclerosis during hyperhomocysteinemia