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Additionally, vitamin E may not be biologically important as an AT, but rather as a signaling molecule and regulator of specific gene expressions ( Various structurally related derivatives of vitamin E have been developed, some of which have improved antioxidant effects with in vitro AT assays or animal models

2.1 Dysbiosis of intestinal flora A reduction in the abundance and diversity of specific bacterial genera in the gut microbiota, as well as alterations in microbiota-derived metabolites, has been identified as a potential key factor in the pathogenesis of IBD (28, 29)

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Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma