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Parallel increases in markers of oxidative stress during sleep deprivation demonstrate that the capacity to undergo redox reactions is biochemically constrained during time spent awake by the availability of NAD+ as an oxidizing substrate [7,8]

They did note that deep lesions had altered bacterial profiles (less Lactobacillus , more Alishewanella , Enterococcus and Pseudomonas ), suggesting that different lesions may support different bacterial populations 31

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110 Studies have shown that the two PPIase domains were not involved in the chaperone activity in vivo , as a truncated SurA mutant missing the P1 and P2 domains was functional