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The most clinically advanced approach is that taken by DIOSynVax (Digitally Immune Optimised Synthetic Vaccines), who have partnered with PharmaJet for a first-in-human needle-free intradermal vaccine pEVAC-PS encoding their synthetic antigen T2_17 based on coronavirus RBD sequences (Table 3) [152]

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It may be due to the reduction of hepatocytes in cirrhosis patient, which promotes the secretion of HGF and then activates c-Met to increase hepatocytes proliferation

Consider how warm it got, how long it was warm, and whether you are early or late in the vial life