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This dual mechanism, weight-mediated and insulin-mediated aromatase reduction, may explain why some endometriosis patients see improvements that seem disproportionate to their weight loss alone

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A more stringent mitochondrial content threshold of 5% was applied to the data, but all the remaining filters of the pipeline were disabled because the data had already been filtered

Interestingly, ABHD5 mutations causative in CDS do not co-localize to LDs and are unable to stimulate PNPLA2 lipolytic activity (30), demonstrating an important function for the interaction in the etiology of CDS and lipid storage