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Cuproptosis disrupts mitochondrial-nuclear crosstalk, causing genomic instability: Energy sensing: ATP depletion activates the AMP-activated protein kinase (AMPK) pathway, inhibiting mammalian target of rapamycin complex 1 (mTORC1)-mediated protein synthesis
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Mutations in UPSrelated genes, such as parkin and UCHL1 , compromise ubiquitin tagging or removal, hindering substrate recognition and clearance [169]
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Other metabolic pathways Glutamine is the most abundant and versatile amino acid in the body and provides a substrate for many biosynthetic processes [29]

The muscle preservation argument Weight loss from GLP-1 agonists typically includes 25 to 40% lean tissue loss
