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Flies were entrained to LD cycles of 12 h of 10,000 K white LED and 12 h of complete darkness for 4 days to generate synchronized rhythmicity

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104 However, this route presents significant challenges: the acidic environment of the GI tract can degrade peptides, and impaired intestinal absorptionparticularly in IBD patients with compromised digestive functionfurther reduces bioavailability

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