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Penetration of BBB One of the major hurdles in treating PD is overcoming the BBB, which can be efficiently achieved by surface modification of the NPs

Heteroatom-rich carbon cathodes toward high-performance flexible zinc-ion hybrid supercapacitors

This effect was blocked by NMDA receptor antagonist MK-801 (90 nmol, intraventricular injection), indicating that D-SIP reduces HPA axis activation by inhibiting NMDA receptor signaling

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In addition, it was reported that up-regulation of xCT through the mTOR pathway enhanced pheomelanin production and inhibited eumelanin formation, which altered the overall melanin synthesis in mice [92]

Furthermore, a pharmacokinetic study in rats showed higher brain levels after intranasal delivery of lipid sumatriptan nanoparticles compared to intravenous application [266]