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Additionally, tachykinins, neuropeptides primarily expressed by neurons in the gut [190], are also tied to distortions in both pain transmission as well as intestinal motility [193,194,195,196], and inhibition of tachykinin pathways offers a potential target for treatment in IBS patients [197]

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For example, CONSORT is a guide to reporting the results of RCTs, while developing the trial protocol itself is covered by the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) guidelines [41]

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