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KRAS mutation upregulated lipase H ( LIPH ) expression, enhancing the infiltration of tumor-associated macrophages (TAMs), Treg cells, and Th2/Th1 cells into the TME, while reducing the infiltration of CD8+ T cells and Th1 cells

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Vedolizumab is currently approved by the National Institute of Health and Care Excellence (NICE) for moderate-to-severe active CD if anti-TNF treatment has failed, or if anti-TNF agents cannot be tolerated or are contraindicated[92]

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10.3390/biom12101385 [DOI] [PMC free article] [PubMed] [Google Scholar] 75.Rask SM, Luoto KE, Solismaa A, Jokinen E, Jussila A, Kampman O