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Together, these results suggest that the complement system, particularly C4A, may play a key role in the gene-environment interactions of schizophrenia by modulating the gut microbiota and systemic immune activation status

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To gain a better understanding of the mechanism of resistance and of possible candidate genes that are involved in the Sw-7 resistance response, several categories of genes, including those encoding nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins, defense-related proteins, transcription factors, protein kinases, as well as those related to phytohormone signaling, cell wall, photosynthesis, gene silencing, and microRNA target genes, were further analyzed as follows

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