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discovered that increasing SOD activity significantly lowers the incidence of kidney stone formation and kidney injury, highlighting SODs ability to inhibit autophagy and endoplasmic stress response ( 5.2 The role of vitamin E in the treatment of kidney stones Vitamin E, a fat-soluble antioxidant, plays a critical role in protecting polyunsaturated fatty acids within cell membranes from oxidative damage, thereby preserving cell membrane integrity ( 5.3 The role of tea polyphenols in the treatment of kidney stones Tea contains a collection of polycyclic phenolic compounds known as tea polyphenols, primarily consist of flavanols like catechins, along with flavan derivatives such as theaflavins (TF) and thearubigins (TR) ( Research has found that NF-B can regulate the expression of genes encoding adhesion molecules, COX-2, and inflammatory cytokines (such as TNF-, IL-6, and CRP)

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Any consideration of combination pharmacotherapy should involve shared decision-making, thorough discussion of risks and benefits, and close clinical follow-up

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Therefore, understanding GR activity is essential in research focusing on oxidative stress and related diseases