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Healthy subcutaneous and omental adipose tissue is associated with high expression of extracellular matrix components

Pharmacol Res 52(4):313320 Sunagawa S, Shirakura T, Hokama N, Kozuka C, Yonamine M, Namba T, Morishima S, Nakachi S, Nishi Y, Ikema T, Okamoto S, Matsui C, Hase N, Tamura M, Shimabukuro M, Masuzaki H (2019) Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: a pilot exploratory study

59 Furthermore, the combination of LABA and LAMA provides additional benefits over the individual components used alone without significantly increasing the risk of adverse effects

The molecular gutliver signaling, we substantially revised the manuscript with detailed discussions of key pathways: TLR4/NF-B, MAPK signaling, tight junction regulation, microbial metabolite signaling (e.g., SCFAs), and cytokine cascades

Importantly, these side effects tend to be transient and often decrease as patients adjust to the medication

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