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There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention

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Using saccharin as a prototype sweetener at a dose corresponding to the ADI for humans (5 mg/kg per day), the authors further characterised the faecal microbiota composition of saccharin-consuming mice and demonstrated that saccharin induced strong dysbiosis, with an increase in the number of bacteria from the Bacteroides genus and the Clostridiales order

Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas

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On the other hand, Mujica-Parodi et al